Low concentrations of human neutrophil peptide ameliorate experimental murine colitis

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Low concentrations of human neutrophil peptide ameliorate experimental murine colitis

Human neutrophil peptides (HNPs) not only have antimicrobial properties, but also exert multiple immunomodulatory effects depending on the concentration used. We have previously demonstrated that the intraperitoneal administration of high-dose HNP-1 (100 µg/day) aggravates murine dextran sulfate sodium (DSS)-induced colitis, suggesting a potential pro-inflammatory role for HNPs at high concentr...

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ژورنال

عنوان ژورنال: International Journal of Molecular Medicine

سال: 2016

ISSN: 1107-3756,1791-244X

DOI: 10.3892/ijmm.2016.2795